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Nitroglycerin topical anal

An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide NO in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume reduced preload and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance reduced afterload , thereby decreasing myocardial oxygen demands. In addition, nitroglycerine causes coronary artery dilatation, thereby improving myocardial blood distribution. Topical use of nitroglycerin for anal fissures by nursing mothers appears to have no adverse effects on their breastfed infants.
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Anal Fissure: A Common Cause of Anal Pain

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Glyceryl trinitrate rectal ointment for anal fissure: information | Patient

Medically reviewed by Drugs. Last updated on Feb 4, Intra-anal treatment of moderate to severe pain associated with chronic anal fissure. Chronic anal fissure is thought to be related to sustained high resting anal sphincter tone and associated anodermal ischemia. Apply using a finger covering e. Gently insert ointment into the anal canal no further than to the first finger joint using the covered finger; also apply around the side of the anal canal. Discard the used finger covering and wash hands after application of the ointment.
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Nitroglycerin ointment for anal fissures

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Language: English French. Surgical sphincterotomy for chronic anal fissure can cause fecal incontinence. This has led to the investigation of nonsurgical treatment options that avoid permanent damage to the internal anal sphincter.
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